Associate Scientist II/Senior Associate Scientist (In Vivo Pharmacology, EEG Experience)
COMPANY DESCRIPTION:
Building on our founders’ Nobel-prize winning discoveries in RNA interference, Atalanta Therapeutics is developing novel branched siRNA therapeutics to treat severe neurological diseases at the root cause. With two active partnerships with large biopharmaceutical companies plus a robust and growing internal pipeline, Atalanta is poised to make a difference in patients’ lives. Atalanta fosters a culture of integrity, respect, collaboration, opportunity, learning, and fun. We are located in Boston’s vibrant Seaport district near South Station.
POSITION SUMMARY:
Atalanta is seeking a highly skilled and motivated Associate/Senior Associate Scientist to join the in vivo pharmacology group to support Atalanta’s drug discovery programs. This individual will have hands-on experience in performing in vivo studies involving behavioral and EEG analysis, brain and tissue collection, and in processing CNS tissue and molecular analysis to assess target gene and protein expression. We are seeking candidates who thrive in a team-oriented, fast-paced, and cross-disciplinary small biotech environment.
The Associate/Senior Associate Scientist will be responsible for assay development and execution of experiments to determine the biodistribution, pharmacodynamic properties and efficacy of oligonucleotides in research and preclinical studies supporting multiple drug discovery programs and platform discovery research.
RESPONSIBILITIES:
- Work closely with pharmacology team members to design and execute assays to assess the pharmacological activity, biodistribution and efficacy of oligos in research and preclinical studies to support development of oligonucleotide therapies for neurodegenerative diseases.
- Perform behavioral studies and EEG experiments to assess treatment efficacy of compounds.
- Perform various molecular and biochemical assays on tissue samples from preclinical studies for a variety of CNS drug development programs, including quantitative and qualitative analysis of target mRNAs and proteins.
- Manage tissue analysis and oversee the transfer and storage of samples from rodent and large animal studies performed at Atalanta or at external CRO facilities.
- Independent analysis and interpretation of data, careful documentation of experiments and presentation of results within the company.
QUALIFICATIONS:
- A Bachelor’s degree with a minimum of 2-5 plus years of industry and/or academic experience OR a Master’s degree with a minimum of 0-2 plus years of industry and/or academic experience; Position level commensurate with experience
- Hands-on experience conducting in vivo studies involving behavioral analysis, intracranial electrode implantation, electrophysiological measurements, EEG data evaluation and analysis is required
- Experience in CNS tissue harvesting and processing including rodent brain collection, sample collection from large animal brain and spinal cord and tissue homogenization would be desired
- Hands-on experience in molecular and biochemical assays including DNA/RNA isolation, qRT-PCR, and ELISA, in situ hybridization preferred but not required
- Ability to work independently with strong sense of self-motivation, excellent organization skills with strong attention to detail is required
- Strong communication skills required (oral and written)
- Ability to adapt and exercise flexibility for changing platform needs, workflows, and projects
- Eager to learn, curious about neuroscience, and ready to make meaningful contributions to science
Please submit your CV and cover letter to careers@atalantatx.com and include the position title in the subject line
Atalanta is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.
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