Scientist I/Scientific Technical Leader, In Vitro Electrophysiology (Neuroscience Biology)
Building on our founders’ Nobel-prize winning discoveries in RNA interference, Atalanta Therapeutics is developing novel branched siRNA therapeutics to treat severe neurological diseases at the root cause. With two active partnerships with large biopharmaceutical companies plus a robust internal pipeline, Atalanta is poised to make a difference in patients’ lives. Atalanta fosters a culture of integrity, respect, collaboration, opportunity, learning, and fun. We are located in Boston’s vibrant Seaport district near South Station.
Atalanta is seeking a highly skilled and motivated Scientific Technical Leader who thrives in a team-oriented and cross-disciplinary small biotech environment to join our Neuroscience Biology team. As a subject matter expert, the selected individual will lead the development and execution of rigorous electrophysiology assays to prioritize lead compounds and test mechanism of action of target knockdown in disease models. The successful candidate will have experience and demonstrated expertise building and implementing slice electrophysiology and/or patch-clamp recordings in cultured cells, plus experience in pharmacology. The candidate will be responsible for providing ion channel and neurophysiology expertise to a diverse research team consisting of neuroscience, in vivo pharmacology, in vitro biology, siRNA chemistry, and bioinformatics experts.
- Rigorously design, lead, and execute in vitro/ex vivo electrophysiology protocols and assays. This primarily includes whole-cell patch-clamp in acute brain slices, with additional experience in and/or ability to learn pharmacology of isolated currents in cultured or acutely isolated cells.
- Design and build electrophysiology rigs and establish thorough analysis pipelines for data collected.
- Collaborate with multiple project teams and provide subject matter expertise on ion channels and neurophysiology to the broader research organization.
- Independently analyze and interpret data, carefully document experiments, and present results within the company.
- Ph.D. in Neuroscience, Cell Biology, or related field with a minimum of 0-2 years of industry and/or post-doctoral experience, or -OR- a Master’s degree with a minimum of 8 years of industry experience.
- Extensive experience designing, establishing, and executing whole-cell patch-clamp electrophysiology assays.
- Expertise working with acute brain slice preparations and, ideally, primary neuronal cultures.
- Strong understanding and practical experience with neuropharmacological assay development and optimization.
- Ability to communicate complex neurophysiological and neuropharmacological concepts to a non-specialist audience.
- Ability to work and think independently and contribute as a part of a highly matrixed team.
- Excellent communication skills (oral and written) and attention to detail.
- Experience performing whole-cell patch-clamp recordings in in vitro heterologous expression models.
- Familiarity with additional modalities, such as optoelectronics or multielectrode array recording systems is desirable but not required.
- Experience with molecular and cellular biology, including stable cell line generation, histology, and biochemical assays probing ion channel function.
Please submit your CV and cover letter to email@example.com with the title of the position in the subject line of your email
Atalanta is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.Back to Jobs